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Clinical Evidence and Methodology

EVIDENCE SYNTHESIS

Clinical Reference Hub

Curated insights • How it Works • Practical Pearls • Evidence Base

CLINICAL INSIGHT

When to Use

When to Use

  • Assessment of cardiac output adjusted for body size (Body Surface Area).
  • Essential for identifying cardiogenic shock (CI < 2.2 L/min/m2).
  • Monitoring response to inotropic therapy or mechanical circulatory support.
CLINICAL INSIGHT

How it Works

Formula

Clinical Thresholds

Normal CI
Cardiogenic Shock
Severe Low Output
CLINICAL INSIGHT

Practical Pearls

Why indexing matters

A cardiac output of 4.0 L/min might be normal for a small elderly woman (BSA 1.5 m2, CI 2.6) but would be dangerously low for a large young man (BSA 2.2 m2, CI 1.8). Always index to BSA for clinical decision-making.

CLINICAL INSIGHT

Next Steps

Complementary Calculators

CLINICAL INSIGHT

Evidence Base

Hemodynamic Standards

Catheterization of the heart in man with use of a flow-directed balloon-tipped catheter.

Swan HJ, Ganz W, Forrester J, et al.N Engl J Med.1970

Cardiac Output Index

Cardiac Index (CI): Normalizes Cardiac Output (CO) to Body Surface Area (BSA).

EVIDENCE SYNTHESIS

Clinical Reference Hub

Curated insights • How it Works • Practical Pearls • Evidence Base

CLINICAL INSIGHT

When to Use

When to Use

  • Assessment of cardiac output adjusted for body size (Body Surface Area).
  • Essential for identifying cardiogenic shock (CI < 2.2 L/min/m2).
  • Monitoring response to inotropic therapy or mechanical circulatory support.
CLINICAL INSIGHT

How it Works

Formula

Clinical Thresholds

Normal CI
Cardiogenic Shock
Severe Low Output
CLINICAL INSIGHT

Practical Pearls

Why indexing matters

A cardiac output of 4.0 L/min might be normal for a small elderly woman (BSA 1.5 m2, CI 2.6) but would be dangerously low for a large young man (BSA 2.2 m2, CI 1.8). Always index to BSA for clinical decision-making.

CLINICAL INSIGHT

Next Steps

Complementary Calculators

CLINICAL INSIGHT

Evidence Base

Hemodynamic Standards

Catheterization of the heart in man with use of a flow-directed balloon-tipped catheter.

Swan HJ, Ganz W, Forrester J, et al.N Engl J Med.1970