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AGEP Score
AGEP Validation Score (EuroSCAR): Differentiates Acute Generalized Exanthematous Pustulosis from other drug eruptions.
Morphology (Pustules)
No
Yes
Erythema
No
Yes
Rapid Evolution (<10d)
No
Yes
Fever ≥ 38°C
No
Yes
Neutrophils > 7000/μL
No
Yes
Compute Validation Score
Guidelines & Evidence
Clinical Details
Section 1
When to Use
When to Use
Differentiating Acute Generalized Exanthematous Pustulosis (AGEP) from other pustular eruptions.
Evaluating drug-induced pustular reactions for standardized diagnosis.
Section 2
Formula & Logic
Scoring Criteria
Morphology: Pustules, Erythema, Distribution.
Course: Fever (≥38°C), Duration/Evolution.
Histology: Subcorneal/Intraepidermal pustules, papillary edema.
Section 3
Pearls/Pitfalls
Pearls
AGEP usually occurs within 24-48 hours of drug exposure (most commonly antibiotics).
Resolution is typically rapid (within 15 days) after drug withdrawal, characterized by pinpoint desquamation.
Section 4
Next Steps
Interpretation
0-3: Unlikely AGEP
4-7: Probable AGEP
8-12: Definite AGEP
Section 5
Evidence Appraisal
Primary Reference
Acute generalized exanthematous pustulosis (AGEP) - a clinical reaction pattern.
Sidoroff A et al.
•
Br J Dermatol
. 2001;145(3):389-93
Last Comprehensive Review: 2026
Related Dermatology Tools
7-Point Dermoscopy Checklist
ABSI
AJCC Melanoma Staging
ALDEN Algorithm
Body Surface Area
Breslow & Clark Microstaging
BWH SCC Staging
CTCAE Skin Toxicity
DLQI
EASI Score
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