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mWHO Cardiac Risk

EVIDENCE SYNTHESIS

Clinical Reference Hub

Curated insights • How it Works • Practical Pearls • Evidence Base

CLINICAL INSIGHT

When to Use

Primary Clinical Uses

  • Pre-conception counseling for women with structural or functional heart disease.
  • Directing the frequency of multidisciplinary maternal-fetal and cardiology surveillance during pregnancy.
  • Determining absolute contraindications to pregnancy.

Hemodynamic Crisis

Pregnancy induces a 50% increase in blood volume and cardiac output. The mWHO scale predicts which diseased hearts will catastrophically decompensate under this unique, 9-month physiologic stress test.

CLINICAL INSIGHT

How it Works

Class I & II (Low to Moderate Risk)

Class I
Class II
Class II-III

Class III & IV (High to Extreme Risk)

Class III
Class IV
CLINICAL INSIGHT

Practical Pearls

Notorious Pitfalls

  • Pulmonary Arterial Hypertension (PAH) carries a maternal mortality rate of 20-50%. If a Class IV patient presents pregnant, termination is strongly medically advised.
  • Mechanical valves (Class III) are incredibly difficult to manage. Warfarin is highly teratogenic, but switching to heparin exponentially increases the risk of maternal mechanical valve thrombosis and death. It strictly requires a highly specialized cardio-obstetrics team.
  • Peri-partum cardiomyopathy is a uniquely unpredictable, often catastrophic heart failure that develops in the last month of pregnancy or first few months postpartum, regardless of prior baseline.
CLINICAL INSIGHT

Next Steps

Management Triggers

  • Class I: Routine prenatal care with 1-2 cardiology visits.
  • Class II: Delivery at local hospital is generally safe; cardiology review every trimester.
  • Class III: Requires delivery at a highly-resourced tertiary care center with cardiothoracic surgery on standby. Bi-monthly cardiology/MFM visits.
  • Class IV: If patient refuses termination, requires extreme surveillance. Planned early delivery (often via planned C-section in a cardiac OR) with intensive care team.
CLINICAL INSIGHT

Evidence Base

European Society of Cardiology

2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy.

Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, et al.Eur Heart J.2018
CLINICAL INSIGHT

Background

Evolution of Maternal Cardiology

Historically, women with complex congenital heart disease did not survive into childbearing age. Surgical advancements created an entirely new demographic of pregnant women with repaired (but not normal) hearts, necessitating the creation of the mWHO index.