Curated insights • How it Works • Practical Pearls • Evidence Base
| Level (ng/mL) | Typical Causes |
|---|---|
| < 25 | Normal Range |
| 25 – 100 | Drugs, Stalk Effect, Hypothyroidism, PCOS, Macroprolactin |
| 100 – 250 | Microprolactinoma, Risperidone, Metoclopramide |
| > 250 | Macroprolactinoma (almost certainly) |
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline.
If hyperprolactinaemia is found in an asymptomatic patient, consider "macroprolactin" (a complex of prolactin and IgG) which is biologically inactive but reacts in assays.