What are the limitations of the dipss plus mf?

While the dipss plus mf is highly validated, it should not replace clinical judgment. OpiCalc provides the latest evidence-based limitations for the dipss plus mf to ensure safe bedside use and optimal diagnostic accuracy.

How does the dipss plus mf compare to other Hematology scores?

The dipss plus mf is a gold-standard diagnostic tool. OpiCalc provides side-by-side clinical guidance to help clinicians choose the most specific evidence-based tool for their patient's presentation.

Is the dipss plus mf free to use?

Yes. OpiCalc provides the dipss plus mf completely ad-free and optimized for mobile bedside use, ensuring you can calculate medical risk swiftly and without distraction.

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DIPSS (MF)

DIPSS (Myelofibrosis): The Dynamic International Prognostic Scoring System allows for continuous risk assessment throughout the clinical course of Primary Myelofibrosis.

DIPSS Total Score

0

Risk Group

Low

Median Survival: ~14.2y

Guidelines & Evidence

Clinical Details

Section 1

When to Use

Prognostication in patients with Primary Myelofibrosis (PMF) during the course of their disease.

Differentiating risk groups to determine the timing of referral for allogeneic stem cell transplant.

Monitoring disease progression in patients previously classified by IPSS at diagnosis.

Patient Population

Clinically indicated for patients with Primary Myelofibrosis (PMF). Can also be applied to post-Polycythemia Vera (post-PV) and post-Essential Thrombocythemia (post-ET) myelofibrosis.

When Not to Rely on This Score Alone

At the moment of diagnosis — the IPSS (International Prognostic Scoring System) is the standard for first-time assessment.

To predict transformation to AML — while DIPSS correlates with AML risk, specialized molecular scores (e.g., MIPSS70) provide better genetic resolution.

To guide Jakafi (Ruxolitinib) dosing — dosing is primarily based on platelet counts and symptom burden, not prognostic group.

Section 2

Formula & Logic

Scoring Variables

Variable	Criteria	Weight
Age	> 65 years	1
White Blood Cell Count	> 25 × 10⁹/L	1
Haemoglobin	< 10 g/dL	2
Circulating Blasts	≥ 1%	1
Constitutional Symptoms	Present (Fever, sweats, weight loss)	1

Risk Groups

Points	Risk Group	Median Survival (years)
0	Low	Not reached (~14)
1 - 2	Intermediate-1	14.2
3 - 4	Intermediate-2	4.0
5 - 6	High	1.5

Section 3

Pearls/Pitfalls

Why "Dynamic"?

Unlike the IPSS, which uses only data available at diagnosis, the DIPSS can be recalculated at any point during outpatient follow-up. This allows clinicians to capture the prognostic impact of declining haemoglobin or rising blast counts over time.

The Haemoglobin Multiplier

DIPSS assigns 2 points for anemia (< 10 g/dL), acknowledging its role as the strongest clinical predictor of survival in myelofibrosis.

Section 4

Evidence Appraisal

Primary Score

A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT.

Passamonti F et al. • Blood. 2010;115(9):1703-8.

View Source

Section 5

Literature

Development

Developed by the International Working Group for Myelofibrosis Research and Treatment (IWG-MRT) based on an analysis of 884 patients.

Last Comprehensive Review: 2026

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IPSS-R

IPSS-M

WHO 2022 AML Classification Mapper

ELN 2022 AML Risk Classification

SOKAL Score

EUTOS Score

ELTS Score

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