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Hepatic Iron Index

Hepatic Iron Index: Measures iron accumulation per year of life. Useful for distinguishing between HH and other liver pathologies.

Hepatic Iron (µmol/g dry wt)

Age (Years)

Guidelines & Evidence

Clinical Details

Section 1

When to Use

Clinical Use

Differentiating hereditary hemochromatosis (HH) from other causes of iron overload (e.g., alcoholic liver disease).

Calculating the rate of iron accumulation relative to age.

Traditionally used during liver biopsy assessment.

Section 2

Formula & Logic

Calculation

Hepatic Iron Index = Hepatic Iron Concentration (µmol/g dry weight) / Age (years)

Section 3

Pearls/Pitfalls

Interpretation

Value	Interpretation
> 1.9	Strongly suggestive of homozygous Hereditary Hemochromatosis
< 1.5	Suggestive of non-HH iron overload (e.g. chronic liver disease)

Last Comprehensive Review: 2026

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