This tool supports structured infectious-disease decision making but does not replace clinician judgement or local guideline pathways.
This OpiCalc infectious-disease entry reflects commonly used guideline criteria and bedside risk features used in contemporary clinical practice.
HBV Post-Exposure Prophylaxis: HBV exposure prophylaxis depends on source status and vaccine response.
Source HBsAg positive or unknown high-risk
+3 Points
Unvaccinated
+2 Points
Known vaccine non-responder
Incomplete vaccine series
+1 Points
Prompt presentation after exposure
Documented protective anti-HBs
-4 Points
Assessment Tier
Score 0
Documented immunity usually means no further HBV prophylaxis is needed.