Active TB (HRZE) Dosing: Based on 2021 WHO/IDSA weight tiers. Dosages apply to the 2-month Intensive Phase.
Isoniazid (H)
300mg
300mg max
Rifampin (R)
600mg
600mg max
Pyrazinamide (Z)
1500mg
Hepatotoxicity
Ethambutol (E)
1200mg
Optic Neuritis
Schedule Recommendation
Consider extending continuation phase to 7 months for cavitary disease + positive 2-month culture. Provide Pyridoxine (B6) daily.