Respiratory rate > 20 breaths/min OR PaCO2 < 32 mmHg
WBC count > 12,000 /µL, < 4,000 /µL, OR > 10% band forms
Utility & Limitations
SIRS is highly sensitive but lacks specificity for sepsis (Sepsis-3). Many non-infectious conditions (PE, MI, surgery) trigger SIRS. However, it remains a useful trigger for diagnostic workup.
CLINICAL INSIGHT
Evidence Base
Validation
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis.
Bone RC, et al.Chest.1992
SIRS
SIRS Criteria: Systemic Inflammatory Response Syndrome. A high-sensitivity clinical screen. Note that SIRS is non-specific for sepsis (Sepsis-3 definition).
Inflammatory markers
Physiological Stress Status
SIRS Negative (0/4)
Less than 2 criteria met. Low probability of systemic inflammatory response syndrome.