Risk stratification of cancer patients presenting with febrile neutropenia (Absolute Neutrophil Count < 500 /µL)
Identifying low-risk patients who can safely receive outpatient oral therapy
Predicting the likelihood of serious medical complications (e.g., hypotension, ICU admission, mortality)
CLINICAL INSIGHT
How it Works
Scoring Criteria (Points)
Burden of illness: No/Mild symptoms (5) | Moderate symptoms (3)
No hypotension (SBP > 90 mmHg) (5)
No COPD (4)
Solid tumor OR No prior fungal infection (4)
No dehydration requiring IV fluids (3)
Outpatient status at time of fever (3)
Age < 60 years (2)
Interpretation
Score ≥ 21
Score < 21
Exclusion Criteria
Age < 16 years (not validated)
Comorbidities requiring hospitalization independent of the MASCC score
CLINICAL INSIGHT
Evidence Base
Validation
The Multinational Association for Supportive Care in Cancer risk index: A multinational scoring system for identifying low-risk febrile neutropenic cancer patients.
Klastersky J, et al.J Clin Oncol.2000
MASCC Score
MASCC Index: Identifies low-risk febrile neutropenia patients. A score ≥21 suggests serious complications are unlikely.
Triage Inventory
Disposition Status
High Risk (5)
Inpatient hospitalization and IV antibiotics required.