What are the limitations of the deauville score?

While the deauville score is highly validated, it should not replace clinical judgment. OpiCalc provides the latest evidence-based limitations for the deauville score to ensure safe bedside use and optimal diagnostic accuracy.

How does the deauville score compare to other Hematology scores?

The deauville score is a gold-standard diagnostic tool. OpiCalc provides side-by-side clinical guidance to help clinicians choose the most specific evidence-based tool for their patient's presentation.

Is the deauville score free to use?

Yes. OpiCalc provides the deauville score completely ad-free and optimized for mobile bedside use, ensuring you can calculate medical risk swiftly and without distraction.

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Deauville Score Interpreter

Deauville Score: A 5-point visual scale for interpreting FDG-PET/CT scans in lymphoma. Uses the mediastinum and liver as internal standards for uptake and comparison.

Guidelines & Evidence

Clinical Details

Section 1

When to Use

Interim and end-of-treatment assessment of FDG-PET/CT scans in Hodgkin Lymphoma (HL) and certain Non-Hodgkin Lymphomas (NHL).

Determining treatment response (Complete Response vs. Partial Response).

Decision support for response-adapted therapy (e.g., escalating/de-escalating chemotherapy).

Patient Population

Primarily used in patients with FDG-avid lymphomas, specifically Hodgkin Lymphoma and Diffuse Large B-cell Lymphoma (DLBCL).

When Not to Rely on This Score Alone

Non-avid lymphomas (e.g., CLL/SLL, Marginal Zone Lymphoma) — PET uptake may be naturally low and unreliable.

Inflammatory conditions — Sarcoidosis, infection, or recent surgery can cause false-positive uptake (mimicking Grade 4/5).

Primary CNS Lymphoma — uptake characteristics differ from systemic lymphoma.

Section 2

Formula & Logic

Grading scale

Score	Definition	Interpretation
1	No uptake above background	Negative
2	Uptake ≤ mediastinum (blood pool)	Negative
3	Uptake > mediastinum BUT ≤ liver	Negative (in most settings)
4	Uptake moderately > liver	Positive
5	Uptake markedly > liver and/or new lesions	Positive
X	New areas of uptake unlikely to be lymphoma	Unclear

Section 3

Pearls/Pitfalls

The Liver Reference

The liver is the most critical reference point. In interim PET scans, a Score 1-3 is generally considered a complete metabolic response (CMR). A score 4-5 indicates residual disease.

Clinical Consequences

In some protocols (e.g., R-CHOP for DLBCL), a Deauville 3 at the end of treatment is still considered a "negative" result, whereas in others, it might warrant closer monitoring.

Section 4

Evidence Appraisal

Primary Scale

Report on the First International Workshop on Interim-PET-Scan in Lymphoma.

Meignan M et al. • Leukemia & Lymphoma. 2009;50(8):1257-1260.

View Source

Role of Imaging in the Staging and Response Assessment of Lymphoma: Lugano Classification.

Barrington SF et al. • Journal of Clinical Oncology. 2014;32(27):3048-3058.

View Source

Section 5

Literature

Development

The score was developed during a workshop in Deauville, France, to replace the qualitative "positive/negative" reporting with a more objective 5-point visual scale using internal reference organs (mediastinum and liver).

Last Comprehensive Review: 2026

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JAK2V617F Allele Burden Interpreter

Sokal/EUTOS/ELTS Comparison

IPSID / Lugano Classification

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